An endogenous protein might become a candidate for drug development

The Nurr1 protein has for a long time been considered a promising target for the treatment of Parkinson’s disease. However, its application as a drug has had no chance of success yet.
Researchers have modified the protein Nurr1 so that it can enter cells from the outside. Nurr1 deficiency may be one of the causes of Parkinson’s disease. Even though Nurr1 has been discussed as a potential target for the treatment of Parkinson’s disease, it is unusable in its normal form, as it cannot penetrate cells. A team from Ruhr-Universität Bochum and the US-American National Institutes of Health (NIH) deployed a bacterial import signal in order to deliver Nurr1 into cells. The researchers also demonstrated that the modified protein may have a positive effect on the survival of dopamine-producing nerve cells. They describe their results in the journal Molecular Neurobiology from 18 August 2018.

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Chemiker, Biochemiker, 2-Fach BA


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RUB ranks highly in chemistry

In the Funding Atlas 2018, published by the German Research Foundation (DFG), Ruhr-Universität Bochum is top tier in the discipline chemistry.

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MCIC 2018

The second Materials Chain International Conference, MCIC 2018, will take place from November 12 to November 14 2018 in Bochum, Germany.

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